Reiman et al. (2012) performed gene expression arrays on isogenic FLCN-null and FLCN-expressing cells. They found 708 genes to be differentially expressed in the two cell lines. Of particular interest, multiple genes in the cadherin, Wnt and apoptosis signalling pathways were dysregulated in FLCN null cells.
This work was funded by the Myrovlytis Trust, through a grant awarded to Professor Eamonn Maher at the University of Birmingham, UK.